Examination of Hippo Signalling in Real Time, in Vivo

Grant number: 1157737 | Funding period: 2019 - 2023

Completed

Abstract

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Here, we will investigate the Hippo signalling pathway, which is an important regulator of organ growth and is mutated in many human cancers. We will monitor the movement of different Hippo pathway proteins, in cells of growing Drosophila organs, in real time. This will provide novel insights into normal organ growth and pathogenic organ growth in diseases such as cancer.

Related publications (3)

Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription

B Kroeger, SA Manning, V Mohan, J Lou, G Sun, S Lamont, AJ McCann, M Francois, JM Polo, E Hinde, KF Harvey

2025-07-25

Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that con..

The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other's chromatin binding dynamics and transcription in vivo

SA Manning, B Kroeger, Q Deng, E Brooks, Y Fonseka, E Hinde, KF Harvey

2024-07-08

The Hippo pathway is an important regulator of organ growth and cell fate. The major mechanism by which Hippo is known to control ..

NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development

J Hudson, S Paul, A Veraksa, A Ghabrial, KF Harvey, C Poon

2023-03-01

The Germinal Center Kinase III (GckIII) pathway is a Hippo-like kinase module defined by sequential activation of Ste20 kinases Th..

University of Melbourne Researchers

Kieran Harvey